Research & Publications

1. Ambrose JA, Loures-Vale A, Javed U, Buhari,C and Aftab W. Angiographic correlates in Type 1 and 2 myocardial infarction. JACC Imaging, 2012:5:463-4
2. Srikanth S. Ambrose JA. Pathophysiology of coronary thrombus formation and adverse consequences of thrombus during PCI. Current Card Rev, 2012:8;168-176
3. Srikanth S, Ambrose JA. Coronary thrombus: pathophysiology and consequences. Argentine  J of  Interv Cardiol, 2012;3: 9-17
4. Katikireddy CK, Mann N, Brown D, Van Tosh A, Stergiopoulos K. Evaluation of myocardial ischemia and viability by noninvasive cardiac imaging. Expert Rev Cardiovasc Ther. 2012 Jan;10(1):55-73. doi: 10.1586/erc.11.161.
5. Rathi S, Deedwania PC. The epidemiology and pathophysiology of heart failure. Med Clin North Am. 2012 Sep;96(5):881-90. doi: 10.1016/j.mcna.2012.07.011.
6. Ambrose JA, Berg R. Revisiting angiographic narrowing prior to AMI. JACC Imaging ,2013 (in press)
7. Sy F, Basraon J, Hong, Z, Singh M, Richina J and Ambrose JA. Frequency of takotsubo cardiomyopathy in postmenopausal women presenting with an ACS. Am J cardiol, 2013 (in press)
8. Berg, R and Lim M. Complications of PCI. In Kern (Ed.) Interventional Cardiac Catheterization Handbook 3rd edition. Philadelphia, Elsevier Saunders 2013
9. Sing M, Bolla VH, Berg R.  A case of in-stent thrombosis in a patient with drug eluting stents during perioperative management with glycoprotein IIb/IIIa inhibitors. Catheterization and Cardiovascular Interventions. 2013 doi:10.1002/ccd.24845 [epub ahead of print]
10. Bethel MA, Chacra AR, Deedwania P, Fulcher GR, Holman RR, Jenssen T, Kahn SE, Levitt NS, McMurray JJ, Califf RM, Raptis SA, Thomas L, Sun JL, Haffner SM. A Novel Risk Classification Paradigm for Patients With Impaired Glucose Tolerance and High Cardiovascular Risk. Am J Cardiol. 2013 Apr 19. doi:pii: S0002-9149(13)00815-1. 10.1016/j.amjcard.2013.03.019.
11. Deedwania P, Shea J, Chen W, Brener L. Effects of add-on nebivolol on blood pressure and glucose parameters in hypertensive patients with prediabetes. J Clin Hypertens (Greenwich). 2013 Apr;15(4):270-8. doi: 10.1111/jch.12071. Epub 2013 Feb 1.
12. Deedwania P. Diabetes, cardiovascular disease, and ethnicity. J Am Coll Cardiol. 2013 Apr 30;61(17):1787-9. doi: 10.1016/j.jacc.2013.01.059. Epub 2013 Feb 28. No abstract available.
13. Gupta R, Deedwania PC, Achari V, Bhansali A, Gupta BK, Gupta A, Mahanta TG, Asirvatham AJ, Gupta S, Maheshwari A, Saboo B, Jali MV, Singh J, Guptha S, Sharma KK. Normotension, prehypertension, and hypertension in urban middle-class subjects in India: prevalence, awareness, treatment, and control. Am J Hypertens. 2013 Jan;26(1):83-94. doi: 10.1093/ajh/hps013.
14. Deedwania PC. New oral anticoagulants in elderly patients with atrial fibrillation. Am J Med. 2013 Apr;126(4):289-96. doi: 10.1016/j.amjmed.2012.10.012. Epub 2013 Jan 28. Review.
15. Deedwania PC Ivabradine in heart failure: hope or hype? . Am J Cardiovasc Drugs. 2012 Dec 1;12(6):357-9. doi: 10.2165/11642100-000000000-00000. No abstract available.
16. Deedwania P, Huang GW. An update on antithrombotic therapy in atrial fibrillation: the role of newer and emergent drugs. Rev Cardiovasc Med. 2012;13(2-3):e89-104. Review.
17. Naidu H, Noordzij JP, Samim A, Jalisi S, Grillone GA. Comparison of efficacy, safety, and cost-effectiveness of in-office cup forcep biopsies versus operating room biopsies for laryngopharyngeal tumors. J Voice. 2012 Sep;26(5):604-6. doi: 10.1016/j.jvoice.2011.10.003. Epub 2012 Apr 20.
18. Spruill TM, Feltheimer SD, Harlapur M, Schwartz JE, Ogedegbe G, Park Y, Gerin W. Are there consequences of labeling patients with prehypertension? An experimental study of effects on blood pressure and quality of life. J Psychosom Res. 2013 May;74(5):433-8. doi: 0.1016/j.jpsychores.2013.01.009. Epub 2013 Feb 15.
19. Ye S, Shaffer JA, Kang MS, Harlapur M, Muntner P, Epel E, Guernsey D, Schwartz JE, Davidson KW, Kirkland S, Honig LS, Shimbo D. Relation between leukocyte telomere length and incident coronary heart disease events (from the 1995 Canadian Nova Scotia Health Survey). Am J Cardiol. 2013 Apr 1;111(7):962-7. doi: 10.1016/j.amjcard.2012.12.017. Epub 2013 Jan 29.
20. Barua R, Ambrose JA. Mechanisms of coronary thrombis in cigarette smoke exposure. Arterio Thromb Vasc Bio 2013 (in press)

1. Ambrose JA, Lardizabal J. Stable and Unstable Atherosclerotic Disease: Definitions, clinical  manifestations and pathophysiology. Coronary Atherosclerosis (Ed Arampatzis, McFadden, Michalis   Virmani and Serruys). Informa Healthcare, London 2012
2. Ambrose JA. Managing coronary thrombus in the cath lab during PCI- introduction and editorial comment. Guest editor- John A Ambrose. Curr Card Rev 2012;8:167 and 200

1. Srikanth S, Kotak K, Kiel R, Bajwa M, Swanson E, Sy F, Tandon A,  Waqqas A, Vale A, Ambrose JA.A single controlled exposure to second hand smoke does not alter thrombogenesis or cause platelet activation. ACC 2012
2. Kamal Kotak, John Ambrose, Manmeet Singh, Sarkis Baghdasarian, Paul Mills, Ralph Brindis. Public reporting of outcomes affects patient selection for percutaneous coronary intervention in patients with out of hospital cardiac arrest and ST elevation myocardial infarction. ACC 2013
3. Fridolin Sy MD, Jagroop Basraon DO, Hong Zheng DO, Manminder Singh MD, John A. Ambrose MD. Takotsubo cardiomyopathy may be more common than previously reported in postmenopausal women presenting as ACS. ACC 2013
4. Fridolin Sy MD, Jagroop Basraon DO, Hong Zheng DO, Manminder Singh MD, John A. Ambrose MD. Takotsubo cardiomyopathy may be more common than previously reported in postmenopausal women presenting as ACS. ACC 2013

Kamal Kotak:

Co-Investigator
PI: Dr John Ambrose, MD, FACC
Emphasis: Secondhand smoking and Platelet Activation

Title: A single controlled exposure to second hand smoke does not alter thrombogenesis or cause platelet activation
Clinical Question: Does single episode of controlled exposure to second hand smoke lead to platelet activation?
Design: Evaluation of platelet activation and aggregation using Flowcytometry before and after a single controlled exposure to second hand smoking
Summary of findings: A single controlled exposure to second hand smoke does not alter thrombogenesis or cause platelet activation
Status: Abstract in JACC and Poster Presentation ACC 2012 Meeting

Sub-Investigator-VA Medical Center, Fresno, CA – (August 2012)
TOPCAT (A Trial for Heart Failure in Patients with Preserved Systolic Function)
SPONSOR: National Institutes of Health

Primary Objective: An evaluation of Spironolactone in patients with heart failure and preserved ejection fraction (EF >45%)
Sub-Investigator-VA Medical Center, Fresno, CA
Trial Completed – All Data submitted

Co- Investigator
Emphasis: Out of Hospital Cardiac Arrest and STEMI

Title: Decision making in patients presenting with STEMI and Out of hospital Cardiac arrest
Clinical Question: In patients presenting with STEMI and out of hospital cardiac arrest, Who should and should not be brought to cath lab acutely
Design: ACC sponsored nationwide on-line survey
Status: Abstracts presented at ACC Meeting 2013, San Francisco

Nabil Shafi:
Title: Cardiac MRI for evaluation of Heart Failure with Preserved Ejection Fraction.

Dr. John A. Ambrose: Pubmed List
Dr. Ryan Berg: Pubmed List
Dr. Sarkis Baghdasarian: Pubmed List
Dr. Enrique V. Carbajal: Pubmed List
Dr. Prakash C. Deedwania: Pubmed List
Dr. Mouatou Mouanoutoua: Pubmed List
Dr. Henning Rasmussen: Pubmed List
Dr. Ralph J. Wessel: Pubmed List